Dr Sean Preston, Consultant Gastroenterologist
Dr Sean Preston
Consultant Gastroenterologist
Dr Sean Preston BSc (Hons) PhD MBBS FRCP
Consultant Gastroenterologist
Dr Sean Preston
Consultant Gastroenterologist BSc (Hons) PhD MBBS FRCP
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Areas of expertise
- Gastro-oesophageal reflux (heartburn)
- Achalasia
- Barrett’s oesophagus
- Diagnostic and theraputic endoscopy
- Irritable bowel syndrome (IBS)
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Make an appointment
Address
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The Princess Grace Hospital
42-52 Nottingham Place, London, W1U 5NY
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London Digestive Health
41 Welbeck Street, 2nd Floor, London, W1G 8DU
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London Digestive Centre
41 Welbeck Street, London, W1G 8EA
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Telephone or video consultation
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About Dr Sean Preston
GMC number: 4230881
Year qualified: 1995
Place of primary qualification: University of London
Dr Sean Preston is a leading consultant gastroenterologist with extensive expertise in the diagnosis and management of digestive disorders. He is Medical Director and Director of Endoscopy at The Princess Grace Hospital and serves as Chair of Digestive Diseases and Renal Department for HCA Healthcare UK. With a strong background in clinical practice, research, and medical leadership, he is recognised for his contributions to gastrointestinal health and endoscopic innovation.
He specialises in the management of conditions such as gastro-oesophageal reflux disease (GORD), Barrett’s oesophagus, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and functional gastrointestinal disorders. His clinical approach integrates advanced diagnostic techniques with personalised treatment plans, including dietary interventions and the use of prebiotics and probiotics to optimise gut health. He is particularly focused on the role of the gastrointestinal microbiota in overall wellbeing and disease prevention.
Dr Preston has extensive experience in endoscopic procedures, including diagnostic and therapeutic gastroscopy, colonoscopy, and endoscopic ultrasound. He is an accredited colonoscopist for the National Bowel Cancer Screening Programme, a position that requires continuous performance monitoring and adherence to rigorous quality standards. His endoscopic expertise also extends to the early detection and management of gastrointestinal cancers, an area in which he has published widely. His PhD research at Cancer Research UK investigated the role of stem cells in gastrointestinal malignancies, leading to several influential publications in the field.
In addition to his clinical and research work, Dr Preston has held significant leadership roles in medical education and professional organisations. He was President of the Gastroenterology and Hepatology Section of the Royal Society of Medicine from 2015 to 2017 and previously chaired the Specialists’ Committee for the Independent Doctors’ Federation. He is also a Deputy Director of the North East London NHS Bowel Cancer Screening Programme, contributing to public health initiatives aimed at early cancer detection and prevention.
Recognised for his excellence in patient care and medical innovation, he has been featured in leading publications, including the Tatler Doctors Guide and Spears 500 Top Recommended UK Private Doctors and Surgeons. As a founding partner of London Digestive Health at the London Digestive Centre, he collaborates with a multidisciplinary team of gastroenterologists, surgeons, radiologists, oncologists, and dietitians to deliver comprehensive, patient-centred care.
Areas of expertise
- Achalasia
- Barrett’s oesophagus
- Bloating
- BRAVO pH capsule monitoring
- Coeliac disease
- Colon cancer
- Colonoscopy
- Constipation
- Diagnostic and therapeutic endoscopy
- Diarrhoea
- Endoscopic ultrasound
- Eosinophilic oesophagitis
- Food intolerance
- Gastro-oesophageal reflux disease (GORD) or acid reflux
- General gastroenterology
- Heartburn
- Inflammatory bowel disease
- Irritable bowel syndrome (IBS)
- Oesophageal cancer
- Rectal bleeding
- Small intestinal bacterial overgrowth
Frequently asked questions
What are the common symptoms that your patients tend to present with?
The most common symptoms my patients have are abdominal pain, bloating and heartburn. These can signify serious underlying disease, but can equally be very straightforward problems to solve.
The gastrointestinal tract has the potential to cause many varied symptoms, so it's important to identify the cause as soon as possible.
What are the treatments that you're able to offer your patients?
The treatment is very pathology and patient-specific and it's very important to treat any underlying problems in a holistic manner. These can either be with lifestyle changes, medications, complex endoscopic therapies, dietary manipulation or hypnotherapy. I'm lucky enough to work in a group that can provide all of these.
What are your areas of sub-specialist interest?
My main areas of subspecialist interests are endoscopic, both the diagnosis and treatment of pre-malignant and cancerous pathology in the oesophagus, stomach, pancreas and colon.
Professional memberships
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Articles by Dr Sean Preston
Eicosatetraynoic and eicosatriynoic acids, lipoxygenase inhibitors, block meiosis via antioxidant action.
Transport and selective utilization of adenosine as a prosubstrate for luteinizing hormone-sensitive adenylate cyclase in the luteal cell
The antigonadotropic action of prostaglandin F2 alpha is not mediated by elevated cytosolic calcium levels in rat luteal cells.