Dr Sean Preston, Consultant Gastroenterologist

Dr Sean Preston

Consultant Gastroenterologist

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Dr Sean Preston BSc (Hons) PhD MBBS FRCP

Consultant Gastroenterologist

BSc (Hons) PhD MBBS FRCP

Dr Sean Preston

Consultant Gastroenterologist BSc (Hons) PhD MBBS FRCP

Book online
|
BSc (Hons) PhD MBBS FRCP
HCA-Healthcare-UK

Areas of expertise

  • Gastro-oesophageal reflux (heartburn)
  • Achalasia
  • Barrett’s oesophagus
  • Diagnostic and theraputic endoscopy
  • Irritable bowel syndrome (IBS)
HCA-Healthcare-UK

Recommendations for Dr Preston

These recommendations are for information purposes only. Doctors providing recommendations do so in good faith and are not responsible for clinical outcomes.

Recommended by:

  • byDr Elaine Tickle, GP

    Dr Preston is an enthusiast for delivering excellence in patient care. He is thoroughly up to date and manages patients carefully and with humour and compassion. He is my husband's physician and I am very glad he is on our team!

  • byDr Julian Stanbury Bashforth, GP

    Recommended Gastroenterologist

  • byDr George Webster, Gastroenterologist and Hepatologist

    Excellent general gastroenterologist, with a specialist interest in oesophago-gastric problems.

  • byDr Alastair O'Brien, Gastroenterologist

    Sean is a great all-round Gastroenterologist.

  • by Dr Yiannis Kallis, Consultant Hepatologist & Gastroenterologist

    Excellent clinical skills, highly competent advanced endoscopist

  • by Mr Jonathan Wilson, Consultant Colorectal & General Surgeon

    Recommended Gastroenterologist

  • by Mr Dan Wood, Consultant Urologist

    Recommended Gastroenterologist

  • byDr Elaine Tickle, GP

    Dr Preston is an enthusiast for delivering excellence in patient care. He is thoroughly up to date and manages patients carefully and with humour and compassion. He is my husband's physician and I am very glad he is on our team!

  • byDr Julian Stanbury Bashforth, GP

    Recommended Gastroenterologist

  • byDr George Webster, Gastroenterologist and Hepatologist

    Excellent general gastroenterologist, with a specialist interest in oesophago-gastric problems.

  • byDr Alastair O'Brien, Gastroenterologist

    Sean is a great all-round Gastroenterologist.

  • by Dr Yiannis Kallis, Consultant Hepatologist & Gastroenterologist

    Excellent clinical skills, highly competent advanced endoscopist

  • by Mr Jonathan Wilson, Consultant Colorectal & General Surgeon

    Recommended Gastroenterologist

  • by Mr Dan Wood, Consultant Urologist

    Recommended Gastroenterologist

  • Address

    About Dr Sean Preston

    GMC number: 4230881

    Year qualified: 1995

    Place of primary qualification: University of London

    Dr Sean Preston is a leading consultant gastroenterologist with extensive expertise in the diagnosis and management of digestive disorders. He is Medical Director and Director of Endoscopy at The Princess Grace Hospital and serves as Chair of Digestive Diseases and Renal Department for HCA Healthcare UK. With a strong background in clinical practice, research, and medical leadership, he is recognised for his contributions to gastrointestinal health and endoscopic innovation.

    He specialises in the management of conditions such as gastro-oesophageal reflux disease (GORD), Barrett’s oesophagus, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and functional gastrointestinal disorders. His clinical approach integrates advanced diagnostic techniques with personalised treatment plans, including dietary interventions and the use of prebiotics and probiotics to optimise gut health. He is particularly focused on the role of the gastrointestinal microbiota in overall wellbeing and disease prevention.

    Dr Preston has extensive experience in endoscopic procedures, including diagnostic and therapeutic gastroscopy, colonoscopy, and endoscopic ultrasound. He is an accredited colonoscopist for the National Bowel Cancer Screening Programme, a position that requires continuous performance monitoring and adherence to rigorous quality standards. His endoscopic expertise also extends to the early detection and management of gastrointestinal cancers, an area in which he has published widely. His PhD research at Cancer Research UK investigated the role of stem cells in gastrointestinal malignancies, leading to several influential publications in the field.

    In addition to his clinical and research work, Dr Preston has held significant leadership roles in medical education and professional organisations. He was President of the Gastroenterology and Hepatology Section of the Royal Society of Medicine from 2015 to 2017 and previously chaired the Specialists’ Committee for the Independent Doctors’ Federation. He is also a Deputy Director of the North East London NHS Bowel Cancer Screening Programme, contributing to public health initiatives aimed at early cancer detection and prevention.

    Recognised for his excellence in patient care and medical innovation, he has been featured in leading publications, including the Tatler Doctors Guide and Spears 500 Top Recommended UK Private Doctors and Surgeons. As a founding partner of London Digestive Health at the London Digestive Centre, he collaborates with a multidisciplinary team of gastroenterologists, surgeons, radiologists, oncologists, and dietitians to deliver comprehensive, patient-centred care.

    Areas of expertise

    • Achalasia
    • Barrett’s oesophagus
    • Bloating
    • BRAVO pH capsule monitoring
    • Coeliac disease
    • Colon cancer
    • Colonoscopy
    • Constipation
    • Diagnostic and therapeutic endoscopy
    • Diarrhoea
    • Endoscopic ultrasound
    • Eosinophilic oesophagitis
    • Food intolerance
    • Gastro-oesophageal reflux disease (GORD) or acid reflux
    • General gastroenterology
    • Heartburn
    • Inflammatory bowel disease
    • Irritable bowel syndrome (IBS)
    • Oesophageal cancer
    • Rectal bleeding
    • Small intestinal bacterial overgrowth

    Frequently asked questions

  • What are the common symptoms that your patients tend to present with?

    The most common symptoms my patients have are abdominal pain, bloating and heartburn. These can signify serious underlying disease, but can equally be very straightforward problems to solve.

    The gastrointestinal tract has the potential to cause many varied symptoms, so it's important to identify the cause as soon as possible.

  • What are the treatments that you're able to offer your patients?

    The treatment is very pathology and patient-specific and it's very important to treat any underlying problems in a holistic manner. These can either be with lifestyle changes, medications, complex endoscopic therapies, dietary manipulation or hypnotherapy. I'm lucky enough to work in a group that can provide all of these.

  • What are your areas of sub-specialist interest?

    My main areas of subspecialist interests are endoscopic, both the diagnosis and treatment of pre-malignant and cancerous pathology in the oesophagus, stomach, pancreas and colon.

  • Professional memberships

    British Society of Gastroenterology
    General Medical Council
    American Society for Gastrointestinal Endoscopy
    Royal College of Physicians

    Articles by Dr Sean Preston

    Oxidative stress and the ovary

    Luteinizing hormone depletes ascorbic acid in preovulatory follicles

    Antioxidants reversibly inhibit the spontaneous resumption of meiosis

    Eicosatetraynoic and eicosatriynoic acids, lipoxygenase inhibitors, block meiosis via antioxidant action.

    Hormone induction of ascorbic acid transport in immature granulosa cells

    Oocyte maturation is regulated by modulation of the action of FSH in cumulus cells

    Luteolytic actions of peroxide in rat ovarian cells

    Transport and selective utilization of adenosine as a prosubstrate for luteinizing hormone-sensitive adenylate cyclase in the luteal cell

    The antigonadotropic action of prostaglandin F2 alpha is not mediated by elevated cytosolic calcium levels in rat luteal cells.

    Adenosine reverses calcium-dependent inhibition of follicle-stimulating hormone action and induction of maturation in cumulus-enclosed rat oocytes

    Other specialists recommended by Dr Preston